Colistin Resistance-Mediated Bacterial Surface Modification Sensitizes Phage Infection | Zendy

Guijuan Hao | Zendy; Annie I. Chen | Zendy; Ming Liu | Zendy; Haijian Zhou | Zendy; Marisa S. Egan | Zendy; Xiaoman Yang | Zendy; Biao Kan | Zendy; Hui Wang | Zendy; Mark Goulian | Zendy; Jun Zhu | Zendy

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Colistin Resistance-Mediated Bacterial Surface Modification Sensitizes Phage Infection

Author(s) -

Guijuan Hao,

Annie I. Chen,

Ming Liu,

Haijian Zhou,

Marisa S. Egan,

Xiaoman Yang,

Biao Kan,

Hui Wang,

Mark Goulian,

Jun Zhu

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01609-19

Subject(s) - colistin , klebsiella pneumoniae , lytic cycle , microbiology and biotechnology , bacteria , biology , phage therapy , plasmid , polymyxin , antibiotics , bacteriophage , biofilm , virology , escherichia coli , gene , genetics , virus

Colistin is a drug of last resort for the treatment of many multidrug-resistant Gram-negative bacteria, including carbapenem-resistantKlebsiella pneumoniae (CRKP). However, bacteria readily acquire resistance to this antibiotic via lipopolysaccharide modifications caused by spontaneous mutations or from enzymes acquired by lateral gene transfer. The fitness cost associated with these modifications remains poorly understood.

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