Molecular Epidemiology of Escherichia coli Sequence Type 131 and Its H30 and H30-Rx Subclones among Extended-Spectrum-β-Lactamase-Positive and -Negative E. coli Clinical Isolates from the Chicago Region, 2007 to 2010 | Zendy

Ritu Banerjee | Zendy; Ari Robicsek | Zendy; Michael A. Kuskowski | Zendy; Stephen B. Porter | Zendy; Brian Johnston | Zendy; Evgeni V. Sokurenko | Zendy; Veronika Tchesnokova | Zendy; Lance B. Price | Zendy; James R. Johnson | Zendy

Open Access

Molecular Epidemiology of Escherichia coli Sequence Type 131 and Its H30 and H30-Rx Subclones among Extended-Spectrum-β-Lactamase-Positive and -Negative E. coli Clinical Isolates from the Chicago Region, 2007 to 2010

Author(s) -

Ritu Banerjee,

Ari Robicsek,

Michael A. Kuskowski,

Stephen B. Porter,

Brian Johnston,

Evgeni V. Sokurenko,

Veronika Tchesnokova,

Lance B. Price,

James R. Johnson

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01604-13

Subject(s) - virulence , escherichia coli , microbiology and biotechnology , biology , antibiotic resistance , antimicrobial , gene , molecular epidemiology , drug resistance , antibiotics , genotype , genetics

We assessed Escherichia coli ST131 and its H30 and H30-Rx subclones for virulence genes, antimicrobial resistance, and extended-spectrum beta-lactamase (ESBL) type. Although both subclones were associated with ESBL production, H30-Rx isolates had higher resistance scores and were associated specifically with CTX-M-15. Three virulence genes (iha, sat, and iutA) were more prevalent among H30 than non-H30 ST131 isolates. Thus, the H30 and H30-Rx subclones are more antimicrobial resistant and have virulence profiles that are distinct from those of non-H30 ST131 isolates.

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