Open AccessGentian Violet Exhibits Activity against Biofilms Formed by Oral Candida Isolates Obtained from HIV-Infected Patients
Author(s) -
Rana Traboulsi,
Pranab K. Mukherjee,
Jyotsna Chandra,
Robert A. Salata,
Richard J. Jurevic,
Mahmoud A. Ghannoum
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01601-10
Subject(s) - candida albicans , biofilm , microbiology and biotechnology , confocal laser scanning microscopy , biology , chemistry , bacteria , genetics
The effect of gentian violet againstCandida albicans and non-Candida albicans biofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibitCandida albicans germination was also assessed. Gentian violet activity againstCandida biofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibitedCandida germination in a concentration-dependent manner.