Gentian Violet Exhibits Activity against Biofilms Formed by Oral Candida Isolates Obtained from HIV-Infected Patients | Zendy

Rana Traboulsi | Zendy; Pranab K. Mukherjee | Zendy; Jyotsna Chandra | Zendy; Robert A. Salata | Zendy; Richard J. Jurevic | Zendy; Mahmoud A. Ghannoum | Zendy

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Gentian Violet Exhibits Activity against Biofilms Formed by Oral Candida Isolates Obtained from HIV-Infected Patients

Author(s) -

Rana Traboulsi,

Pranab K. Mukherjee,

Jyotsna Chandra,

Robert A. Salata,

Richard J. Jurevic,

Mahmoud A. Ghannoum

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01601-10

Subject(s) - candida albicans , biofilm , microbiology and biotechnology , confocal laser scanning microscopy , biology , chemistry , bacteria , genetics

The effect of gentian violet againstCandida albicans and non-Candida albicans biofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibitCandida albicans germination was also assessed. Gentian violet activity againstCandida biofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibitedCandida germination in a concentration-dependent manner.

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