GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796 | Zendy

Matthew F. McCown | Zendy; Sonal Rajyaguru | Zendy; Simran Kular | Zendy; Nick Cammack | Zendy; Isabel Nájera | Zendy

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GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796

Author(s) -

Matthew F. McCown,

Sonal Rajyaguru,

Simran Kular,

Nick Cammack,

Isabel Nájera

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01598-08

Subject(s) - telaprevir , virology , hepatitis c virus , mutation , viral replication , resistance mutation , virus , hepacivirus , medicine , replication (statistics) , biology , gene , genetics , polymerase chain reaction , reverse transcriptase , ribavirin

In vitro, telaprevir selects subtype-specific resistance pathways for hepatitis C virus GT-1a and GT-1b, as described to have occurred in patients. In GT-1a, the HCV-796 resistance mutation C316Y has low replication capacity (7%) that can be compensated for by the emergence of the mutation L392F or M414T, resulting in an increase in replication levels of > or = 10-fold.

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