Comparison of the Essential Cellular Functions of the Two murA Genes of Bacillus anthracis | Zendy

G. C. Kedar | Zendy; Vickie BrownDriver | Zendy; Daniel R. Reyes | Zendy; M.T. Hilgers | Zendy; Mark A. Stidham | Zendy; Karen Joy Shaw | Zendy; John M. Finn | Zendy; Robert J. Haselbeck | Zendy

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Comparison of the Essential Cellular Functions of the Two murA Genes of Bacillus anthracis

Author(s) -

G. C. Kedar,

Vickie BrownDriver,

Daniel R. Reyes,

M.T. Hilgers,

Mark A. Stidham,

Karen Joy Shaw,

John M. Finn,

Robert J. Haselbeck

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01594-07

Subject(s) - bacillus anthracis , gene , biology , mutagenesis , microbiology and biotechnology , gene expression , fosfomycin , bacteria , genetics , antibiotics , mutation

Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of B. anthracis to this drug.

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