In Vitro Susceptibility of Pythium insidiosum to Macrolides and Tetracycline Antibiotics | Zendy

Érico Silva Loreto | Zendy; Débora Alves Nunes Mario | Zendy; Laura Bedin Denardi | Zendy; Sydney Hartz Alves | Zendy; Jânio Morais Santúrio | Zendy

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In Vitro Susceptibility of Pythium insidiosum to Macrolides and Tetracycline Antibiotics

Author(s) -

Érico Silva Loreto,

Débora Alves Nunes Mario,

Laura Bedin Denardi,

Sydney Hartz Alves,

Jânio Morais Santúrio

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01586-10

Subject(s) - minocycline , tetracycline , pythium , microbiology and biotechnology , antibiotics , erythromycin , in vitro , biology , minimum inhibitory concentration , biochemistry , botany

We describe the in vitro activity of macrolides and tetracycline antibiotics against Pythium insidiosum. The MICs were determined according to CLSI procedures (visual MIC) and by a colorimetric method [3-(4,5-dimethyl-2-thiazyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT)]. The lowest geometric mean (GM) MIC (MICs in μg/ml) (0.39 and 0.7 by visual reading and colorimetric method, respectively) and MIC ranges (0.125 to 2.0) were obtained for minocycline, while the highest MICs were shown for erythromycin (GM of 7.58 and 12.25 by visual reading and colorimetric method, respectively, and MIC ranged from 2 to 32). This significant in vitro activity makes these classes of antibiotics good candidates for experimental treatment of pythiosis.

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