Antibiotic-Induced Autoactivation of IS 256 in Staphylococcus aureus | Zendy

Franziska Schreiber | Zendy; Christiane Szekat | Zendy; Michaele Josten | Zendy; HansGeorg Sahl | Zendy; Gabriele Bierbaum | Zendy

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Antibiotic-Induced Autoactivation of IS 256 in Staphylococcus aureus

Author(s) -

Franziska Schreiber,

Christiane Szekat,

Michaele Josten,

HansGeorg Sahl,

Gabriele Bierbaum

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01585-13

Subject(s) - staphylococcus aureus , linezolid , chloramphenicol , spectinomycin , microbiology and biotechnology , antibiotics , mutant , biology , vancomycin , penicillin , bacteria , genetics , gene

The 3' end of rsbU, encoding the positive regulator of the stress factor sigma B, was identified as a hot spot for spontaneous IS256 insertion in Staphylococcus aureus SA137/93G. Interestingly, subinhibitory concentrations of chloramphenicol in combination with heat stress, as well as linezolid and spectinomycin at physiological temperatures, selected for such rsbU::IS256 insertion mutants. In consequence of the inactivation of rsbU, the IS256 transposition frequency was increased 4-fold in S. aureus HG001.

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