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MultiresistantStaphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosomemec (SCCmec ) element, composed of an SCCmec with strong homologies toStaphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of publishedS. capitis strains suggest that strain CR01 acquired the two elements independently.

antimicrobial agents and chemotherapy

Characterization of a Novel Composite Staphylococcal Cassette Chromosome mec (SCC mec -SCC cad / ars / cop ) in the Neonatal Sepsis-Associated Staphylococcus capitis Pulsotype NRCS-A