Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria | Zendy

Jiyoung Lee | Zendy; Myeongjin Choi | Zendy; Hyeon Jin Choi | Zendy; Kwan Soo Ko | Zendy

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Preservation of Acquired Colistin Resistance in Gram-Negative Bacteria

Author(s) -

Jiyoung Lee,

Myeongjin Choi,

Hyeon Jin Choi,

Kwan Soo Ko

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01574-15

Subject(s) - colistin , microbiology and biotechnology , gram negative bacteria , gram negative bacterial infections , bacteria , gram , biology , medicine , antibiotics , escherichia coli , genetics , gene

Colistin-resistant mutants were obtained from 17 colistin-susceptible strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. The stability of colistin resistance in these mutants was investigated. Three of four colistin-resistant P. aeruginosa mutants recovered colistin susceptibility in colistin-free medium; however, colistin-susceptible revertants were obtained from only one strain each of A. baumannii and E. coli. No susceptible revertants were obtained from K. pneumoniae mutants.

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