Activity of Colistin against Heteroresistant Acinetobacter baumannii and Emergence of Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model | Zendy

Chun-Hong Tan | Zendy; Jian Li | Zendy; Roger L. Nation | Zendy

Open Access

Activity of Colistin against Heteroresistant Acinetobacter baumannii and Emergence of Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Author(s) -

Chun-Hong Tan,

Jian Li,

Roger L. Nation

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01571-06

Subject(s) - acinetobacter baumannii , colistin , pharmacodynamics , pharmacokinetics , pharmacology , microbiology and biotechnology , in vitro , acinetobacter , population , medicine , biology , antibiotics , pseudomonas aeruginosa , bacteria , biochemistry , genetics , environmental health

Three clinically relevant intermittent regimens, and a continuous infusion, of colistin were simulated in an in vitro pharmacokinetic/pharmacodynamic model against two colistin-heteroresistant strains of Acinetobacter baumannii. Extensive initial killing was followed by regrowth as early as 6 h later; bacterial density in the 24- to 72-h period was within 1 log(10) CFU/ml of growth control. Population analysis profiles revealed extensive emergence of resistant subpopulations regardless of the colistin regimen.

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