Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing | Zendy

Claire de Curraize | Zendy; Sylvain Kumanski | Zendy; Maïté Micaëlo | Zendy; Nelly Fournet | Zendy; Guy La Ruche | Zendy; F. Meunier | Zendy; Rishma Amarsy | Zendy; Hervé Jacquier | Zendy; Emmanuelle Cambau | Zendy; Agathe Goubard | Zendy; Béatrice Berçot | Zendy

Open Access

Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing

Author(s) -

Claire de Curraize,

Sylvain Kumanski,

Maïté Micaëlo,

Nelly Fournet,

Guy La Ruche,

F. Meunier,

Rishma Amarsy,

Hervé Jacquier,

Emmanuelle Cambau,

Agathe Goubard,

Béatrice Berçot

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01568-16

Subject(s) - neisseria gonorrhoeae , ceftriaxone , biology , neisseriaceae , microbiology and biotechnology , whole genome sequencing , genome , gonorrhea , genetics , virology , antibiotics , gene , human immunodeficiency virus (hiv)

Two extended-spectrum cephalosporin-resistantNeisseria gonorrhoeae isolates were discovered among 6,340 (0.03%) French isolates between 2010 and 2014. One isolate corresponded to the F89 multidrug-resistantN. gonorrhoeae isolate harboring apenA mosaic; whole-genome sequencing highlighted an additional R251H substitution in theftsX gene recently involved in cephalosporin resistance. The other, ceftriaxone-resistant isolate (MIC, 0.25 mg/liter) harbored the PBP2 pattern XXXVI plus a P551S substitution and belonged to sequence type ST1579 (multilocus sequence typing [MLST]).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research