Open AccessReduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment
Author(s) -
John D. Cleary,
Guillermo GarcíaEffrón,
Stanley W. Chapman,
David S. Perlin
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01568-07
Subject(s) - caspofungin , candida glabrata , microbiology and biotechnology , mutation , biology , mycosis , micafungin , echinocandin , fungemia , voriconazole , antifungal , medicine , fluconazole , genetics , gene , immunology
We describe a case of recurringCandida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not. All isolates were clonal, and high-MIC strains contained a mutation in the highly conserved hot spot 1 region of Fks1p.