Open AccessIn Vivo Efficacy of a Novel Oxazolidinone Compound in Two Mouse Models of Infection
Author(s) -
Charles Gill,
George K. Abruzzo,
Amy Flattery,
Andrew S. Misura,
Ken Bartizal,
Emily Hickey
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01567-06
Subject(s) - linezolid , staphylococcus aureus , in vivo , staphylococcal infections , microbiology and biotechnology , methicillin resistant staphylococcus aureus , medicine , antibacterial agent , micrococcaceae , antibiotics , biology , bacteria , vancomycin , genetics
A novel oxazolidinone, AM 7359, was evaluated in two mouse models ofStaphylococcus aureus infection. AM 7359 and linezolid were equally efficacious in a methicillin-susceptibleS. aureus organ burden model and a methicillin-resistantS. aureus localized infection model. However, AM 7359 was eightfold more efficacious than linezolid against a linezolid- and methicillin-resistantS. aureus strain in this localized (thigh) infection model.