Open AccessBinding of Faropenem and Other β-Lactam Agents to Penicillin-Binding Proteins of Pneumococci with Various β-Lactam Susceptibilities
Author(s) -
Klaudia Kosowska-Shick,
Pamela McGhee,
Peter C. Appelbaum
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01566-08
Subject(s) - penicillin binding proteins , imipenem , streptococcus pneumoniae , penicillin , microbiology and biotechnology , antibiotics , thienamycin , cephem , lactam , cephalosporin , biology , chemistry , biochemistry , stereochemistry , antibiotic resistance , carboxylic acid
Faropenem demonstrated low MICs (< or = 1 microg/ml) for all penicillin-susceptible and nonsusceptible pneumococci and exhibited very strong abilities to bind to Streptococcus pneumoniae penicillin-binding proteins (PBPs), except for PBP2X. The lower faropenem affinity for PBP2X did not affect MICs for any strains tested, and only imipenem had lower MICs, with much lower binding affinities for all PBPs tested, than faropenem.
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