Open AccessGES-13, a β-Lactamase Variant Possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa
Author(s) -
Stathis D. Kotsakis,
Costas C. Papagiannitsis,
E. Tzelepi,
Legakis Nj,
Vivì Miriagou,
L. S. Tzouvelekis
Publication year - 2010
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01561-09
Subject(s) - aztreonam , integron , pseudomonas aeruginosa , imipenem , cephalosporin , microbiology and biotechnology , cefsulodin , pseudomonadaceae , biology , pseudomonadales , thienamycin , chemistry , genetics , bacteria , antibiotics , ceftazidime , antibiotic resistance
GES-13 β-lactamase, a novel GES variant possessing Lys-104 and Asn-170, was identified inPseudomonas aeruginosa. bla GES-13 was the single gene cassette of a class 1 integron probably located in the chromosome. GES-13 efficiently hydrolyzed broad-spectrum cephalosporins and aztreonam. Imipenem was a potent inhibitor of GES-13 but was not hydrolyzed at measurable rates.