Comparative In Vivo Antibacterial Activity of Human-Simulated Exposures of Cefiderocol and Ceftazidime against Stenotrophomonas maltophilia in the Murine Thigh Model | Zendy

Iris H. Chen | Zendy; James M. Kidd | Zendy; Kamilia Abdelraouf | Zendy; David P. Nicolau | Zendy

Open Access

Comparative In Vivo Antibacterial Activity of Human-Simulated Exposures of Cefiderocol and Ceftazidime against Stenotrophomonas maltophilia in the Murine Thigh Model

Author(s) -

Iris H. Chen,

James M. Kidd,

Kamilia Abdelraouf,

David P. Nicolau

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01558-19

Subject(s) - stenotrophomonas maltophilia , siderophore , cephalosporin , ceftazidime , pseudomonas aeruginosa , microbiology and biotechnology , biology , in vivo , stenotrophomonas , pseudomonas , bacteria , antibiotics , genetics

Cefiderocol is a novel siderophore cephalosporin that utilizes bacterial ferric iron transports to cross the outer membrane. Cefiderocol shows high stability against all classes of β-lactamases, rendering it extremely potent against carbapenem- and multidrug-resistant Gram-negative organisms.

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