The Inactivation of Intrinsic Antibiotic Resistance Determinants Widens the Mutant Selection Window for Quinolones in Stenotrophomonas maltophilia | Zendy

Guillermo GarcíaLeón | Zendy; María Blanca Sánchez | Zendy; José Luis Martínez | Zendy

Open Access

The Inactivation of Intrinsic Antibiotic Resistance Determinants Widens the Mutant Selection Window for Quinolones in Stenotrophomonas maltophilia

Author(s) -

Guillermo GarcíaLeón,

María Blanca Sánchez,

José Luis Martínez

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01558-12

Subject(s) - stenotrophomonas maltophilia , efflux , mutant , microbiology and biotechnology , ofloxacin , antibiotics , ciprofloxacin , pseudomonas aeruginosa , biology , quinolone , antibiotic resistance , antibacterial agent , bacteria , genetics , gene

We have determined that the mutational inactivation of the SmeDEF efflux pump and the SmQnr quinolone resistance protein widens the mutant selection windows for ofloxacin and ciprofloxacin of Stenotrophomonas maltophilia by reducing their MICs. Resistant mutants arising from a strain lacking SmeDEF and SmQnr presented levels of susceptibility similar to those of the wild-type strain. This indicates that inactivation of intrinsic resistance determinants might increase the chances for selecting resistant mutants at low antibiotic concentrations.

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