Antianaerobic Activity of Sulopenem Compared to Six Other Agents | Zendy

Lois M. Ednie | Zendy; Peter C. Appelbaum | Zendy

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Antianaerobic Activity of Sulopenem Compared to Six Other Agents

Author(s) -

Lois M. Ednie,

Peter C. Appelbaum

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01557-08

Subject(s) - sulbactam , piperacillin , ampicillin , tazobactam , imipenem , metronidazole , clindamycin , amoxicillin , piperacillin/tazobactam , agar dilution , microbiology and biotechnology , clavulanic acid , chemistry , medicine , antibiotics , minimum inhibitory concentration , biology , bacteria , antibiotic resistance , genetics , pseudomonas aeruginosa

Agar dilution MIC methodology was used to compare the activity of sulopenem with those of amoxicillin/clavulanate, ampicillin/sulbactam, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 431 anaerobes. Overall, MIC(50)/(90) values were as follows: sulopenem, 0.25/1.0 microg/ml; amoxicillin/clavulanate, 0.5/2.0 microg/ml; ampicillin/sulbactam, 0.5/4.0 microg/ml; piperacillin/tazobactam, 0.25/8.0 microg/ml; imipenem, 0.06/1.0 microg/ml; clindamycin, 0.25/16.0 microg/ml; and metronidazole, 1.0/4.0 microg/ml.

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