Target-Controlled Infusion of Cefepime in Critically Ill Patients | Zendy

Stijn Jonckheere | Zendy; Nikolaas De Neve | Zendy; Jan Verbeke | Zendy; Koen De Decker | Zendy; Inger Brandt | Zendy; An Boel | Zendy; Jan Van Bocxlaer | Zendy; Michel Struys | Zendy; Pieter Colin | Zendy

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Target-Controlled Infusion of Cefepime in Critically Ill Patients

Author(s) -

Stijn Jonckheere,

Nikolaas De Neve,

Jan Verbeke,

Koen De Decker,

Inger Brandt,

An Boel,

Jan Van Bocxlaer,

Michel Struys,

Pieter Colin

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01552-19

Subject(s) - cefepime , critically ill , dosing , pharmacodynamics , medicine , pharmacokinetics , antibiotics , pharmacology , intensive care medicine , therapeutic drug monitoring , drug , anesthesia , chemistry , antibiotic resistance , biochemistry , imipenem

Attainment of appropriate pharmacokinetic-pharmacodynamic (PK-PD) targets for antimicrobial treatment is challenging in critically ill patients, particularly for cefepime, which exhibits a relative narrow therapeutic-toxic window compared to other beta-lactam antibiotics. Target-controlled infusion (TCI) systems, which deliver drugs to achieve specific target drug concentrations, have successfully been implemented for improved dosing of sedatives and analgesics in anesthesia.

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