Antimicrobial Treatment Provides a Competitive Advantage to Mycobacterium abscessus in a Dual-Species Biofilm with Pseudomonas aeruginosa | Zendy

Graciela Rodríguez-Sevilla | Zendy; Aurélie Crabbé | Zendy; Marta García-Coca | Zendy; John Jairo Aguilera-Correa | Zendy; Jaime Esteban | Zendy; Concepción PérezJorge | Zendy

Open Access

Antimicrobial Treatment Provides a Competitive Advantage to Mycobacterium abscessus in a Dual-Species Biofilm with Pseudomonas aeruginosa

Author(s) -

Graciela Rodríguez-Sevilla,

Aurélie Crabbé,

Marta García-Coca,

John Jairo Aguilera-Correa,

Jaime Esteban,

Concepción PérezJorge

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01547-19

Subject(s) - mycobacterium abscessus , pseudomonas aeruginosa , microbiology and biotechnology , cystic fibrosis , antimicrobial , biofilm , antibiotics , pathogen , biology , mycobacterium , bacteria , genetics

The physiological factors that contribute toMycobacterium abscessus lung infections remain unclear. We determined whether antibiotic treatment targeting a major cystic fibrosis pathogen (i.e.,Pseudomonas aeruginosa ) could provide the ideal conditions for the establishment ofM. abscessus infection. Our data showed thatP. aeruginosa inhibitedM. abscessus biofilm formation under control conditions and that antimicrobial therapy selectively targetingP. aeruginosa diminished this competitive interaction, thereby increasingM. abscessus survival.

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