Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats | Zendy

Shaoqi Qu | Zendy; Cunchun Dai | Zendy; Fengting Lang | Zendy; Longfei Hu | Zendy; Qihe Tang | Zendy; Haixia Wang | Zendy; Yanping Zhang | Zendy; Zhihui Hao | Zendy

Open Access

Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats

Author(s) -

Shaoqi Qu,

Cunchun Dai,

Fengting Lang,

Longfei Hu,

Qihe Tang,

Haixia Wang,

Yanping Zhang,

Zhihui Hao

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01545-18

Subject(s) - rutin , nephrotoxicity , oxidative stress , pharmacology , creatinine , apoptosis , kidney , medicine , blood urea nitrogen , tumor necrosis factor alpha , chemistry , endocrinology , antioxidant , biochemistry

Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment of serious infections caused by multiresistant Gram-positive bacteria. This study investigated the renal protective activity of rutin in a rat model of VCM-induced kidney injury in male Wistar rats.

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