Open AccessArtemisinins Inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense In Vitro Growth
Author(s) -
Yuliya V. Mishina,
Sanjeev Krishna,
Richard K. Haynes,
John C. Meade
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01544-06
Subject(s) - trypanosoma cruzi , trypanosoma brucei rhodesiense , trypanosoma brucei , artemisinin , in vitro , biology , mode of action , biochemistry , chemistry , plasmodium falciparum , parasite hosting , immunology , malaria , world wide web , computer science , gene
Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.