Retrospective Molecular Analysis of DIM-1 Metallo-β-Lactamase Discovered in Pseudomonas stutzeri from India in 2000 | Zendy

Lalitagauri M. Deshpande | Zendy; Ronald N. Jones | Zendy; Leah N. Woosley | Zendy; Mariana Castanheira | Zendy

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Retrospective Molecular Analysis of DIM-1 Metallo-β-Lactamase Discovered in Pseudomonas stutzeri from India in 2000

Author(s) -

Lalitagauri M. Deshpande,

Ronald N. Jones,

Leah N. Woosley,

Mariana Castanheira

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01541-13

Subject(s) - pseudomonas stutzeri , imipenem , microbiology and biotechnology , strain (injury) , biology , pseudomonas , gene , pseudomonadaceae , bacteria , pseudomonadales , antibiotics , genetics , antibiotic resistance , anatomy

Among 220 clinical isolates of Gram-negative bacilli collected in India during 2000, 22 strains showing elevated imipenem MICs were evaluated for carbapenemase production. One DIM-1-producingPseudomonas stutzeri isolate was detected, and no other carbapenemase-encoding genes were identified. This detection of a DIM-1-producingP. stutzeri isolate from India predating the finding of this gene in the index Dutch strain and the very recent detection of DIM-1 in Africa suggest an unidentified environmental source of this metallo-β-lactamase gene.

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