Serum Differentially Alters the Antifungal Properties of Echinocandin Drugs | Zendy

Padmaja Paderu | Zendy; Guillermo GarcíaEffrón | Zendy; Sergey Balashov | Zendy; Gilles Delmas | Zendy; Steven Park | Zendy; David S. Perlin | Zendy

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Serum Differentially Alters the Antifungal Properties of Echinocandin Drugs

Author(s) -

Padmaja Paderu,

Guillermo GarcíaEffrón,

Sergey Balashov,

Gilles Delmas,

Steven Park,

David S. Perlin

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01536-06

Subject(s) - echinocandin , anidulafungin , micafungin , caspofungin , echinocandins , pharmacology , antifungal , antifungal drug , microbiology and biotechnology , drug , biology , medicine , fluconazole

Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.

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