Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors | Zendy

Jan Paeshuyse | Zendy; Inge Vliegen | Zendy; Lotte Coelmont | Zendy; Pieter Leyssen | Zendy; Oriana Tabarrini | Zendy; Piet Herdewijn | Zendy; Harald Mittendorfer | Zendy; Johnny Easmon | Zendy; Violetta Cecchetti | Zendy; Ralf Bartenschlager | Zendy; Gerhard Puerstinger | Zendy; Johan Neyts | Zendy

Open Access

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

Author(s) -

Jan Paeshuyse,

Inge Vliegen,

Lotte Coelmont,

Pieter Leyssen,

Oriana Tabarrini,

Piet Herdewijn,

Harald Mittendorfer,

Johnny Easmon,

Violetta Cecchetti,

Ralf Bartenschlager,

Gerhard Puerstinger,

Johan Neyts

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01534-07

Subject(s) - polymerase , virology , ns3 , hepatitis c virus , hepatitis b virus dna polymerase , nucleotidyltransferase , biology , dna polymerase , replicon , protease , microbiology and biotechnology , virus , enzyme , biochemistry , dna , gene , rna , plasmid

We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) alpha,gamma-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.

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