Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers | Zendy

Russell J Benefield | Zendy; E. Susan Slechta | Zendy; Christopher M. Gast | Zendy; Emily S Spivak | Zendy; Kimberly E. Hanson | Zendy; Donald P. Alexander | Zendy

Open Access

Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers

Author(s) -

Russell J Benefield,

E. Susan Slechta,

Christopher M. Gast,

Emily S Spivak,

Kimberly E. Hanson,

Donald P. Alexander

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01525-18

Subject(s) - daptomycin , medicine , disposition , pharmacokinetics , pharmacology , volume of distribution , drug , liter , drug interaction , biology , vancomycin , psychology , social psychology , bacteria , genetics , staphylococcus aureus

We evaluated the effects of rifampin coadministration andMDR1 single nucleotide polymorphisms on the disposition of daptomycin in twelve healthy adults. There were no significant changes from baseline in the clearance (0.53 versus 0.55 liters/h,P = 1.00), volume of distribution (7.0 versus 7.2 liter,P = 0.62), or half-life (9.7 versus 9.6 h,P = 0.89) of daptomycin after exposure to rifampin.

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