Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus | Zendy

Sun Hee Lee | Zendy; Wan Beom Park | Zendy; Shinwon Lee | Zendy; Sohee Park | Zendy; ShinWoo Kim | Zendy; JongMyung Lee | Zendy; HyunHa Chang | Zendy; Ki Tae Kwon | Zendy; Pyoeng Gyun Choe | Zendy; Nam Joong Kim | Zendy; Hong Bin Kim | Zendy; Myoungdon Oh | Zendy

Open Access

Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus

Author(s) -

Sun Hee Lee,

Wan Beom Park,

Shinwon Lee,

Sohee Park,

ShinWoo Kim,

JongMyung Lee,

HyunHa Chang,

Ki Tae Kwon,

Pyoeng Gyun Choe,

Nam Joong Kim,

Hong Bin Kim,

Myoungdon Oh

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01517-16

Subject(s) - cefazolin , staphylococcus aureus , biology , single nucleotide polymorphism , microbiology and biotechnology , gene , polymorphism (computer science) , genetics , genotype , bacteria , antibiotics

Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research