In Vitro Interactions of Antifungal Agents and Tacrolimus against Aspergillus Biofilms | Zendy

Lujuan Gao | Zendy; Yi Sun | Zendy

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In Vitro Interactions of Antifungal Agents and Tacrolimus against Aspergillus Biofilms

Author(s) -

Lujuan Gao,

Yi Sun

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01510-15

Subject(s) - aspergillus terreus , voriconazole , aspergillus fumigatus , aspergillus flavus , posaconazole , microbiology and biotechnology , itraconazole , checkerboard , aspergillus , amphotericin b , biofilm , caspofungin , broth microdilution , aspergillus versicolor , aspergillosis , aspergillus ochraceus , tacrolimus , minimum inhibitory concentration , chemistry , antifungal , biology , antimicrobial , medicine , bacteria , immunology , mycotoxin , transplantation , food science , genetics , surgery , ochratoxin a

Aspergillus biofilms were prepared from Aspergillus fumigatus, Aspergillus flavus, and Aspergillus terreus via a 96-well plate-based method, and the combined antifungal activity of tacrolimus with azoles or amphotericin B against Aspergillus biofilms was investigated via a broth microdilution checkerboard technique system. Our results suggest that combinations of tacrolimus with voriconazole or amphotericin B have synergistic inhibitory activity against Aspergillus biofilms. However, combinations of tacrolimus with itraconazole or posaconazole exhibit no synergistic or antagonistic effects.

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