In Vitro Activity of Terbinafine Combined with Caspofungin and Azoles against Pythium insidiosum | Zendy

Ayrton Sydnei Cavalheiro | Zendy; Grazieli Maboni | Zendy; Maria I. Azevedo | Zendy; Juliana Siqueira Argenta | Zendy; Daniela Isabel Brayer Pereira | Zendy; Tatiana Borba Spader | Zendy; Sydney Hartz Alves | Zendy; Jânio Morais Santúrio | Zendy

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In Vitro Activity of Terbinafine Combined with Caspofungin and Azoles against Pythium insidiosum

Author(s) -

Ayrton Sydnei Cavalheiro,

Grazieli Maboni,

Maria I. Azevedo,

Juliana Siqueira Argenta,

Daniela Isabel Brayer Pereira,

Tatiana Borba Spader,

Sydney Hartz Alves,

Jânio Morais Santúrio

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01506-08

Subject(s) - terbinafine , caspofungin , miconazole , fluconazole , ketoconazole , microbiology and biotechnology , voriconazole , pharmacology , broth microdilution , checkerboard , biology , itraconazole , antifungal , minimum inhibitory concentration , antibiotics

In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.

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