Multicopy bla OXA-58 Gene as a Source of High-Level Resistance to Carbapenems in Acinetobacter baumannii | Zendy

Alessia Bertini | Zendy; Laurent Poirel | Zendy; Sandrine Bernabeu | Zendy; D. Fortini | Zendy; Laura Villa | Zendy; Patrice Nordmann | Zendy; Alessandra Carattoli | Zendy

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Multicopy bla _OXA-58 Gene as a Source of High-Level Resistance to Carbapenems in Acinetobacter baumannii

Author(s) -

Alessia Bertini,

Laurent Poirel,

Sandrine Bernabeu,

D. Fortini,

Laura Villa,

Patrice Nordmann,

Alessandra Carattoli

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01502-06

Subject(s) - acinetobacter baumannii , plasmid , gene , biology , carbapenem , microbiology and biotechnology , transposition (logic) , acinetobacter , genetics , neisseriaceae , antibiotics , bacteria , pseudomonas aeruginosa , linguistics , philosophy

The mechanisms at the origin of heterogeneous carbapenem resistance levels observed amongAcinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase genebla OXA-58 but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding thebla OXA-58 gene showed genetic variability, with the presence in several isolates of multiple copies of thebla OXA-58 gene; this extra copy number was likely related to an IS26 -mediated transposition or recombination process.

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