Open AccessIn Vitro Antimalarial Activity of Inhibitors of the Human GTPase Rac1
Author(s) -
Silvia Parapini,
Silvio Paone,
Emanuela Erba,
Loredana Cavicchini,
M. Pourshaban,
Francesco Celani,
Alessandro Contini,
Sarah D’Alessandro,
Anna Olivieri
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01498-21
Subject(s) - malaria , plasmodium falciparum , plasmodium (life cycle) , rac1 , virology , drug resistance , biology , gtpase , pharmacology , medicine , immunology , parasite hosting , microbiology and biotechnology , genetics , computer science , signal transduction , world wide web
Malaria accounts for millions of cases and thousands of deaths every year. In the absence of an effective vaccine, drugs are still the most important tool in the fight against the disease.Plasmodium parasites developed resistance to all classes of known antimalarial drugs.