Regulation and Anaerobic Function of the Clostridioides difficile β-Lactamase | Zendy

Brindar K. Sandhu | Zendy; Adrianne N. Edwards | Zendy; Sarah E. Anderson | Zendy; Emily C. Woods | Zendy; Shonna M. McBride | Zendy

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Regulation and Anaerobic Function of the Clostridioides difficile β-Lactamase

Author(s) -

Brindar K. Sandhu,

Adrianne N. Edwards,

Sarah E. Anderson,

Emily C. Woods,

Shonna M. McBride

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01496-19

Subject(s) - clostridioides , anaerobic exercise , microbiology and biotechnology , function (biology) , biology , medicine , genetics , physiology

Clostridioides difficile causes severe antibiotic-associated diarrhea and colitis.C. difficile is an anaerobic, Gram-positive sporeformer that is highly resistant to β-lactams, the most commonly prescribed antibiotics. The resistance ofC. difficile to β-lactam antibiotics allows the pathogen to replicate and cause disease in antibiotic-treated patients. However, the mechanisms of β-lactam resistance inC. difficile are not fully understood.

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