Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection | Zendy

Olivia D. Council | Zendy; Michael D. Swanson | Zendy; Rae Ann Spagnuolo | Zendy; Angela Wahl | Zendy; J. Víctor García | Zendy

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Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection

Author(s) -

Olivia D. Council,

Michael D. Swanson,

Rae Ann Spagnuolo,

Angela Wahl,

J. Víctor García

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01496-15

Subject(s) - maraviroc , semen , sexual transmission , virology , transmission (telecommunications) , immunology , biology , medicine , human immunodeficiency virus (hiv) , andrology , microbicide , electrical engineering , engineering

We used bone marrow/liver/thymus (BLT) humanized mice to establish the effect of semen on vaginal HIV infection and on the efficacy of topically applied maraviroc. Our results demonstrate that vaginal transmission of cell-free HIV occurs efficiently in the presence of semen and that topically applied maraviroc efficiently prevents HIV transmission in the presence of semen. We also show that semen has no significant effect on the transmission of transmitted/founder viruses or cell-associated viruses.

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