Open AccessPse-T2, an Antimicrobial Peptide with High-Level, Broad-Spectrum Antimicrobial Potency and Skin Biocompatibility against Multidrug-Resistant Pseudomonas aeruginosa Infection
Author(s) -
Hee Kyoung Kang,
Chang Ho Seo,
Tudor Luchian,
Yoonkyung Park
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01493-18
Subject(s) - antimicrobial , pseudomonas aeruginosa , antimicrobial peptides , cytotoxicity , microbiology and biotechnology , multiple drug resistance , ciprofloxacin , peptide , biology , in vivo , antibiotics , bacteria , chemistry , in vitro , biochemistry , genetics
Pseudin-2, isolated from the frogPseudis paradoxa , exhibits potent antibacterial activity but also cytotoxicity. In an effort to develop clinically applicable antimicrobial peptides (AMPs), we designed pseudin-2 analogs with Lys substitutions, resulting in elevated amphipathic α-helical structure and cationicity.
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