The Urinary Antibiotic 5-Nitro-8-Hydroxyquinoline (Nitroxoline) Reduces the Formation and Induces the Dispersal of Pseudomonas aeruginosa Biofilms by Chelation of Iron and Zinc | Zendy

Astrid Sobke | Zendy; Matthias Klinger | Zendy; Bertrand Hermann | Zendy; Svea Sachse | Zendy; Sándor Nietzsche | Zendy; Oliwia Makarewicz | Zendy; Peter M. Keller | Zendy; W. Pfister | Zendy; E. Sträube | Zendy

Open Access

The Urinary Antibiotic 5-Nitro-8-Hydroxyquinoline (Nitroxoline) Reduces the Formation and Induces the Dispersal of Pseudomonas aeruginosa Biofilms by Chelation of Iron and Zinc

Author(s) -

Astrid Sobke,

Matthias Klinger,

Bertrand Hermann,

Svea Sachse,

Sándor Nietzsche,

Oliwia Makarewicz,

Peter M. Keller,

W. Pfister,

E. Sträube

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01484-12

Subject(s) - pseudomonas aeruginosa , biofilm , microbiology and biotechnology , antibiotics , zinc , 8 hydroxyquinoline , chelation , chemistry , biological dispersal , bacteria , biology , medicine , population , genetics , organic chemistry , environmental health

Since cations have been reported as essential regulators of biofilm, we investigated the potential of the broad-spectrum antimicrobial and cation-chelator nitroxoline as an antibiofilm agent. Biofilm mass synthesis was reduced by up to 80% at sub-MIC nitroxoline concentrations inPseudomonas aeruginosa , and structures formed were reticulate rather than compact. In preformed biofilms, viable cell counts were reduced by 4 logs at therapeutic concentrations. Complexation of iron and zinc was demonstrated to underlie nitroxoline's potent antibiofilm activity.

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