Open AccessEmergence of the Quinolone Resistance-Mediating Gene aac(6′)-Ib-cr in Extended-Spectrum-β-Lactamase-Producing Klebsiella Isolates Collected in Slovenia between 2000 and 2005
Author(s) -
Jerneja Ambrožič Avguštin,
Rok Keber,
Katja Žerjavič,
T. Oražem,
M. Grabnar
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01480-06
Subject(s) - plasmid , ciprofloxacin , microbiology and biotechnology , escherichia coli , quinolone , enterobacteriaceae , biology , klebsiella , klebsiella pneumoniae , gene , strain (injury) , beta lactamase , antibacterial agent , antibiotics , genetics , anatomy
Seventy-four nonrepetitive uropathogenic fluoroquinolone-resistant or -intermediate extended-spectrum-β-lactamase-producingKlebsiella isolates from Slovenia were screened for the presence of plasmid-mediated quinolone resistance genes. None of the knownqnr genes were detected. Theaac(6′)-Ib-cr allele was detected on plasmids from 25 transconjugants for which the ciprofloxacin MIC was higher than for the recipientEscherichia coli strain.