Novel Types of Staphylococcal Cassette Chromosome mec Elements Identified in Clonal Complex 398 Methicillin-Resistant Staphylococcus aureus Strains | Zendy

Shanshuang Li | Zendy; Robert Skov | Zendy; Xiao Han | Zendy; Anders Rhod Larsen | Zendy; Jesper Larsen | Zendy; Marit Sørum | Zendy; M.W.H. Wulf | Zendy; Andreas Voß | Zendy; Keiichi Hiramatsu | Zendy; Teruyo Ito | Zendy

Open Access

Novel Types of Staphylococcal Cassette Chromosome mec Elements Identified in Clonal Complex 398 Methicillin-Resistant Staphylococcus aureus Strains

Author(s) -

Shanshuang Li,

Robert Skov,

Xiao Han,

Anders Rhod Larsen,

Jesper Larsen,

Marit Sørum,

M.W.H. Wulf,

Andreas Voß,

Keiichi Hiramatsu,

Teruyo Ito

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01475-10

Subject(s) - sccmec , staphylococcus aureus , microbiology and biotechnology , chromosome , methicillin resistant staphylococcus aureus , biology , genetics , staphylococcal infections , gene , bacteria

The structures of staphylococcal cassette chromosomemec (SCCmec ) elements carried by 31 clonal complex 398 (CC398) methicillin-resistantStaphylococcus aureus (MRSA) strains isolated from the participants at a conference were analyzed. The SCCmec s were classified into novel types, namely, IX, X, V(5C2&5) subtype c, and IVa. Type V(5C2&5) subtype c, IX, and X SCCmec s carried genes conferring resistance to metals. The structures of SCCmec s from CC398 strains were distinct from those normally found in humans, adding to the evidence that humans are not the original host for CC398.

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