Antimicrobial Activity of Omiganan Pentahydrochloride against Contemporary Fungal Pathogens Responsible for Catheter-Associated Infections | Zendy

Thomas R. Fritsche | Zendy; Paul R. Rhomberg | Zendy; Hélio S. Sader | Zendy; Ronald N. Jones | Zendy

Open Access

Antimicrobial Activity of Omiganan Pentahydrochloride against Contemporary Fungal Pathogens Responsible for Catheter-Associated Infections

Author(s) -

Thomas R. Fritsche,

Paul R. Rhomberg,

Hélio S. Sader,

Ronald N. Jones

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01475-07

Subject(s) - antimicrobial , microbiology and biotechnology , echinocandins , fungicide , aspergillus , biology , fungi imperfecti , antifungal , amphotericin b , caspofungin , botany

Omiganan, a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections, inhibited commonly occurring fungal pathogens including Candida spp. (106 isolates) at <or=256 microg/ml and molds (including 10 Aspergillus isolates) at <or=1,024 microg/ml. All fungi were inhibited by omiganan at concentrations well below the 1% (10,000 microg/ml) clinical formulation, including species with reduced susceptibility to azoles and echinocandins.

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