Open AccessIntracellular Localization of the ABCC Proteins of Leishmania and Their Role in Resistance to Antimonials
Author(s) -
Philippe Leprohon,
Danielle Légaré,
Marc Ouellette
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01474-08
Subject(s) - intracellular , leishmania , intracellular parasite , microbiology and biotechnology , biology , chemistry , parasite hosting , computer science , world wide web
The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Leishmania.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom