Microdialysis Study of Imipenem Distribution in the Peritoneal Fluid of Rats with Experimental Acute Pancreatitis | Zendy

Sandrine Lefeuvre | Zendy; Sandrine Marchand | Zendy; Claudine Pariat | Zendy; Isabelle Lamarche | Zendy; William Couet | Zendy

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Microdialysis Study of Imipenem Distribution in the Peritoneal Fluid of Rats with Experimental Acute Pancreatitis

Author(s) -

Sandrine Lefeuvre,

Sandrine Marchand,

Claudine Pariat,

Isabelle Lamarche,

William Couet

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01474-07

Subject(s) - peritoneal fluid , microdialysis , imipenem , pancreatitis , distribution (mathematics) , medicine , acute pancreatitis , peritoneum , antibiotics , chemistry , pathology , biochemistry , mathematics , mathematical analysis , antibiotic resistance , central nervous system

Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.

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