Open AccessPreferential Emergence of Reduced Vancomycin Susceptibility in Health Care-Associated Methicillin-Resistant Staphylococcus aureus Isolates during Continuous-Infusion Vancomycin Therapy in an In Vitro Dynamic Model
Author(s) -
Sheryl Zelenitsky,
Noha Alkurdi,
Zhanni Weber,
Robert E. Ariano,
George G. Zhanel
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01472-10
Subject(s) - vancomycin , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , medicine , micrococcaceae , minimum inhibitory concentration , antibiotics , antibacterial agent , biology , bacteria , genetics
Bacterial killing and the development of reduced vancomycin susceptibility during continuous-infusion vancomycin (CIV) therapy were dependent on the area under the concentration-time curve over 24 h divided by the MIC (ƒAUC24 /MIC), with values of ≥240 (equivalent total serum AUC24 /MICs of ≥480) being bactericidal and suppressing emerging resistance in methicillin-resistantStaphylococcus aureus (MRSA). Also, vancomycin therapy was less likely to be bactericidal and 4.4 times more likely to lead to reduced vancomycin susceptibility in health care-associated MRSA than in community-associated MRSA.