The Novel CTX-M-116 β-Lactamase Gene Discovered in Proteus mirabilis Is Composed of Parts of the CTX-M-22 and CTX-M-23 Genes | Zendy

Nadezhda K. Fursova | Zendy; Sergey Pryamchuk | Zendy; Alexander Kruglov | Zendy; Igor Abaev | Zendy; E. Pecherskikh | Zendy; Nikolay N. Kartsev | Zendy; Svetoch Ea | Zendy; I. A. Dyatlov | Zendy

Open Access

The Novel CTX-M-116 β-Lactamase Gene Discovered in Proteus mirabilis Is Composed of Parts of the CTX-M-22 and CTX-M-23 Genes

Author(s) -

Nadezhda K. Fursova,

Sergey Pryamchuk,

Alexander Kruglov,

Igor Abaev,

E. Pecherskikh,

Nikolay N. Kartsev,

Svetoch Ea,

I. A. Dyatlov

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01471-12

Subject(s) - proteus mirabilis , genbank , gene , biology , nucleotide , dna , proteus , nucleic acid sequence , sequence analysis , genetics , microbiology and biotechnology , escherichia coli

The novel β-lactamase genebla CTX-M-116 was identified in aProteus mirabilis nosocomial isolate recovered from the urine of a patient in Moscow in 2005. DNA sequence analysis showedbla CTX-M-116 to be a hybrid gene consisting of 5′bla CTX-M-23 (nucleotides 1 to 278) and 3′bla CTX-M-22 (nucleotides 286 to 876) moieties separated by an intervening putative site of recombination (GTTAAAT). A retrospective analysis of availablebla CTX-M genes in the GenBank database revealed 19bla CTX-M genes that display the same hybrid structure.

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