Synergistic Effect of Antituberculosis Drugs and Azoles In Vitro against Histoplasma capsulatum var. capsulatum | Zendy

Rossana de Aguiar Cordeiro | Zendy; Francisca Jakelyne de Farias Marques | Zendy; Raimunda Sâmia Nogueira Brilhante | Zendy; Kylvia Rocha de Castro e Silva | Zendy; Charles Ielpo Mourão | Zendy; Érica Pacheco Caetano | Zendy; Maria Auxiliadora Bezerra Fechine | Zendy; Joyce Fonteles Ribeiro | Zendy; Débora de Souza Collares Maia CasteloBranco | Zendy; Rita Amanda Chaves de Lima | Zendy; Jacó Ricarte Lima de Mesquita | Zendy; André Jalles Monteiro | Zendy; Francisco Airton Castro Rocha | Zendy; Marcos Fábio Gadelha Rocha | Zendy; José Júlio Costa Sidrim | Zendy

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Synergistic Effect of Antituberculosis Drugs and Azoles In Vitro against Histoplasma capsulatum var. capsulatum

Author(s) -

Rossana de Aguiar Cordeiro,

Francisca Jakelyne de Farias Marques,

Raimunda Sâmia Nogueira Brilhante,

Kylvia Rocha de Castro e Silva,

Charles Ielpo Mourão,

Érica Pacheco Caetano,

Maria Auxiliadora Bezerra Fechine,

Joyce Fonteles Ribeiro,

Débora de Souza Collares Maia CasteloBranco,

Rita Amanda Chaves de Lima,

Jacó Ricarte Lima de Mesquita,

André Jalles Monteiro,

Francisco Airton Castro Rocha,

Marcos Fábio Gadelha Rocha,

José Júlio Costa Sidrim

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01471-10

Subject(s) - pyrazinamide , voriconazole , ethambutol , isoniazid , histoplasma capsulatum , itraconazole , in vivo , microbiology and biotechnology , in vitro , pharmacology , triazole , rifampicin , fluconazole , chemistry , medicine , biology , histoplasmosis , tuberculosis , antifungal , antibiotics , immunology , biochemistry , organic chemistry , pathology

This study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plus triazoles for the mold form and ethambutol plus voriconazole for the yeast-like form. Further studies should evaluate these combinations in vivo.

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