In Vitro Antimycobacterial Activities of Capuramycin Analogues | Zendy

Venkata M. Reddy | Zendy; Leo Einck | Zendy; Carol A. Nacy | Zendy

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In Vitro Antimycobacterial Activities of Capuramycin Analogues

Author(s) -

Venkata M. Reddy,

Leo Einck,

Carol A. Nacy

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01469-07

Subject(s) - antimycobacterial , in vitro , biological activity , pharmacology , microbiology and biotechnology , translocase , antibacterial agent , chemistry , antibiotics , biology , biochemistry , tuberculosis , medicine , mycobacterium tuberculosis , chromosomal translocation , pathology , gene

Translocase I inhibitor compounds derived from capuramycin demonstrated rapid bactericidal activity against several different mycobacterial species. SQ641 was the most active of the compounds, with a MIC of 0.12 to 8 microg/ml, a postantibiotic effect of 55 h, and interesting synergistic effects with other antitubercular drugs.

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