Activity of Posaconazole and Other Antifungal Agents against Mucorales Strains Identified by Sequencing of Internal Transcribed Spacers | Zendy

Ana AlastrueyIzquierdo | Zendy; María Victoria Castelli | Zendy; Isabel Cuesta | Zendy; Araceli Monzón | Zendy; Manuel CuencaEstrella | Zendy; Juan L. Rodrı́guez-Tudela | Zendy

Open Access

Activity of Posaconazole and Other Antifungal Agents against Mucorales Strains Identified by Sequencing of Internal Transcribed Spacers

Author(s) -

Ana AlastrueyIzquierdo,

María Victoria Castelli,

Isabel Cuesta,

Araceli Monzón,

Manuel CuencaEstrella,

Juan L. Rodrı́guez-Tudela

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01467-08

Subject(s) - mucor circinelloides , posaconazole , mucorales , internal transcribed spacer , terbinafine , biology , mucormycosis , microbiology and biotechnology , mucor , rhizopus oryzae , rhizopus , voriconazole , antifungal , itraconazole , aspergillus , medicine , genetics , phylogenetic tree , food science , pathology , gene , fermentation

The antifungal susceptibility profiles of 77 clinical strains of Mucorales species, identified by internal transcribed spacer sequencing, were analyzed. MICs obtained at 24 and 48 h were compared. Amphotericin B was the most active agent against all isolates, except for Cunninghamella and Apophysomyces isolates. Posaconazole also showed good activity for all species but Cunninghamella bertholletiae. Voriconazole had no activity against any of the fungi tested. Terbinafine showed good activity, except for Rhizopus oryzae, Mucor circinelloides, and Rhizomucor variabilis isolates.

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