In Vitro Activity of Proveblue (Methylene Blue) on Plasmodium falciparum Strains Resistant to Standard Antimalarial Drugs | Zendy

Aurélie Pascual | Zendy; Maud Henry | Zendy; Sébastien Briolant | Zendy; Serge Charras | Zendy; Eric Baret | Zendy; Rémy Amalvict | Zendy; Emilie Huyghues des Etages | Zendy; Michel Féraud | Zendy; Christophe Rogier | Zendy; Bruno Pradines | Zendy

Open Access

In Vitro Activity of Proveblue (Methylene Blue) on Plasmodium falciparum Strains Resistant to Standard Antimalarial Drugs

Author(s) -

Aurélie Pascual,

Maud Henry,

Sébastien Briolant,

Serge Charras,

Eric Baret,

Rémy Amalvict,

Emilie Huyghues des Etages,

Michel Féraud,

Christophe Rogier,

Bruno Pradines

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01466-10

Subject(s) - mefloquine , plasmodium falciparum , quinine , lumefantrine , malaria , biology , amodiaquine , chloroquine , methylene blue , minimum inhibitory concentration , pharmacology , drug resistance , in vitro , virology , artemisinin , microbiology and biotechnology , genetics , immunology , biochemistry , photocatalysis , catalysis

The geometric mean 50% inhibitory concentration (IC50 ) for Proveblue, a methylene blue complying with the European Pharmacopoeia, was more active on 23P. falciparum strains than chloroquine, quinine, mefloquine, monodesethylamodiaquine, and lumefantrine. We did not find significant associations between the Proveblue IC50 and polymorphisms in thepfcrt ,pfmdr1 ,pfmdr2 ,pfmrp , andpfnhe-1 genes or the copy numbers of thepfmdr1 andpfmdr2 genes, all of which are involved in antimalarial resistance.

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