Open AccessDecreased Susceptibility to Ciprofloxacin among Shigella Isolates in the United States, 2006 to 2009
Author(s) -
Jason P. Folster,
Gary Pecic,
Anna Bowen,
Regan Rickert,
Alessandra Carattoli,
Jean M. Whichard
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01463-10
Subject(s) - ciprofloxacin , shigella , microbiology and biotechnology , quinolone , cephalosporin , biology , antibiotic resistance , antimicrobial , antibacterial agent , antibiotics , bacteria , salmonella , genetics
We characterized 20Shigella isolates with decreased susceptibility to fluoroquinolones. Most patients (80%) from whom a travel history was obtained reported travel to South or Southeast Asia. Mutations within the quinolone resistance determining regions ofgyrA andparC and plasmid-mediated resistance determinants (qnrB ,qnrS , andaac(6′)-Ib-cr ) were identified. The rise in antimicrobial resistance amongShigella isolates may necessitate the increased use of extended-spectrum cephalosporins or macrolides in some patients.