In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis | Zendy

Adela MartínVicente | Zendy; Javier Capilla | Zendy; Josep Guarro | Zendy

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In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis

Author(s) -

Adela MartínVicente,

Javier Capilla,

Josep Guarro

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01462-15

Subject(s) - posaconazole , aspergillus fumigatus , amphotericin b , aspergillosis , azole , in vivo , drug resistance , microbiology and biotechnology , biology , pharmacology , medicine , antifungal , immunology

Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against threeA. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.

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