Combined Intravenous and Intraventricular Administration of Colistin Methanesulfonate in Critically Ill Patients with Central Nervous System Infection | Zendy

Mairi Ziaka | Zendy; Sophia L. Markantonis | Zendy; Marizoza Fousteri | Zendy; Paris Zygoulis | Zendy; Dimitrios Panidis | Zendy; Marios Karvouniaris | Zendy; Demosthènes Makris | Zendy; Epamidas Zakynthinos | Zendy

Open Access

Combined Intravenous and Intraventricular Administration of Colistin Methanesulfonate in Critically Ill Patients with Central Nervous System Infection

Author(s) -

Mairi Ziaka,

Sophia L. Markantonis,

Marizoza Fousteri,

Paris Zygoulis,

Dimitrios Panidis,

Marios Karvouniaris,

Demosthènes Makris,

Epamidas Zakynthinos

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01461-12

Subject(s) - medicine , critically ill , colistin , central nervous system , anesthesia , intensive care medicine , pharmacology , antibiotics , biology , microbiology and biotechnology

Colistin pharmacokinetics were prospectively studied after intravenous administration of colistin methanesulphonate in critically ill patients without central nervous system infection (controls,n = 5) and in patients with external ventricular drain-associated ventriculitis after intravenous administration (EVDViv,n = 3) or combined intravenous/intraventricular administration (EVDVcomb,n = 4). Cerebrospinal fluid (CSF)/serum colistin concentration ratios were higher in EVDViv than in control patients (11% versus 7%,P ≤ 0.05) and in EVDVcomb compared to all other patients (P < 0.0001). CSF colistin concentrations above the MIC of 0.5 μg/ml were achieved only in EVDVcomb patients.

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