Two Regulators, PA3898 and PA2100, Modulate the Pseudomonas aeruginosa Multidrug Resistance MexAB-OprM and EmrAB Efflux Pumps and Biofilm Formation | Zendy

Yun Kang | Zendy; Zhenxin Sun | Zendy; Jan ZarzyckiSiek | Zendy; Kanchana Poonsuk | Zendy; Ian McMillan | Zendy; Rungtip Chuanchuen | Zendy; Tung T. Hoang | Zendy

Open Access

Two Regulators, PA3898 and PA2100, Modulate the Pseudomonas aeruginosa Multidrug Resistance MexAB-OprM and EmrAB Efflux Pumps and Biofilm Formation

Author(s) -

Yun Kang,

Zhenxin Sun,

Jan ZarzyckiSiek,

Kanchana Poonsuk,

Ian McMillan,

Rungtip Chuanchuen,

Tung T. Hoang

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01459-18

Subject(s) - efflux , pseudomonas aeruginosa , biofilm , microbiology and biotechnology , multiple drug resistance , biology , drug resistance , chemistry , bacteria , biochemistry , genetics

It is generally believed that thePseudomonas aeruginosa biofilm matrix itself acts as a molecular sieve or sink that contributes to significant levels of drug resistance, but it is becoming more apparent that multidrug efflux pumps induced during biofilm growth significantly enhance resistance levels. We present here a novel transcriptional regulator, PA3898, which controls biofilm formation and multidrug efflux pumps inP. aeruginosa .

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